RRNAD1

Across TCGA cell cohorts, RRNAD1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RRNAD1-associated genes across cancer lineages are SPIC, FMO1, and GRM6. Each is linked with RRNAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRNAD1-to-partner and partner-to-RRNAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by RRNAD1-low versus RRNAD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRNAD1→partner) and Y-score (partner→RRNAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPIC →	+0.200	+3.510	<.001	.003	3	2
LARGE_INTESTINE	FMO1 →	+0.117	+3.658	<.001	.005	3	1
LARGE_INTESTINE	GRM6 →	+0.090	+4.115	<.001	.001	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.422	+3.772	<.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.045	+4.187	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SPIC by RRNAD1 expression — LARGE_INTESTINE

Explore this box plot interactively →