RRN3

Across TCGA patient cohorts, RRN3 mutation is significantly associated with the RNA expression of many other genes, with 2,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRN3-associated genes across cancer lineages are COX15, ACAD8, and DCK. Each is linked with RRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRN3-to-partner and partner-to-RRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by RRN3-low versus RRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRN3→partner) and Y-score (partner→RRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.505	+3.087	<.001	<.001	3	2
UCEC	ACAD8 →	+0.435	+3.708	.004	<.001	3	2
UCEC	DCK →	+0.751	+3.098	.001	<.001	3	2
UCEC	FRRS1 →	+0.707	+2.807	.002	.003	3	2
UCEC	H2AZ1 →	+0.601	+4.202	.003	<.001	3	2
UCEC	SARS1 →	+0.398	+2.447	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

COX15 by RRN3 expression — UCEC

Explore this box plot interactively →