RRN3

Across TCGA patient cohorts, RRN3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRN3-associated genes across cancer lineages are Shc_pY317, Caspase-7-cleavedD198, and Di-Ras3. Each is linked with RRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRN3-to-partner and partner-to-RRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by RRN3-low versus RRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRN3→partner) and Y-score (partner→RRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.133	-1.700	.039	.044	3	2
UCEC	Caspase-7-cleavedD198 →	+0.646	+3.341	.010	.005	3	2
UCEC	Di-Ras3 →	-0.133	-2.986	.034	.035	3	2
UCEC	EGFR_pY1068 →	-0.245	-2.222	.021	.011	3	1
UCEC	ERK2 →	+0.172	+1.700	.035	.044	3	1
UCEC	JNK2 →	+0.172	+1.700	.042	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Shc_pY317 by RRN3 expression — UCEC

Explore this box plot interactively →