RRN3

Across TCGA cell cohorts, RRN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,472 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRN3-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Regulation of chromatin organization, and Regulation of heterochromatin organization. Each is linked with RRN3 in more than 16 cancer types. Because this analysis shows association rather than direction, both RRN3-to-partner and partner-to-RRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by RRN3-low versus RRN3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRN3→partner) and Y-score (partner→RRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Symbiont-mediated disruption of host cell PML body →	+0.116	+0.895	.001	<.001	3	17
KIDNEY	Regulation of chromatin organization →	+0.095	+0.473	.001	.007	3	15
LUNG_SCLC	Regulation of heterochromatin organization →	+0.113	+0.454	.003	.007	3	14
LUNG_SCLC	Negative regulation of heterochromatin organization →	+0.124	+0.529	.001	<.001	3	14
LUNG_SCLC	Negative regulation of heterochromatin formation →	+0.124	+0.529	.001	<.001	3	14
LUNG_NSCLC_LUAD	Telomerase RNA stabilization →	+0.108	+0.569	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,472 associations by consensus.

Symbiont-mediated disruption of host cell PML body by RRN3 expression — STOMACH

Explore this box plot interactively →