RRM2P2

Across TCGA pan-cancer cohorts, RRM2P2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RRM2P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RRM2P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRM2P2 is over-expressed in tumor, although a few such as PAAD and KICH show the opposite, repressed pattern.

COAD, STAD, and LIHC are the cancer types where RRM2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRM2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.147	.007	4	view →
STAD	Male	II,III,IV	+0.217	.007	3	view →
LIHC	All	All	+0.030	.013	3	view →
ESCA	All	II,III,IV	+0.560	.027	2	view →
PAAD	Female	All	−0.285	.048	2	view →
CHOL	All	All	+0.205	.002	2	view →
LUAD	All	III,IV	+0.115	.014	2	view →
KICH	Male	All	−0.068	.016	2	view →
BRCA	All	All	+0.063	.028	2	view →
LUSC	All	All	+0.047	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RRM2P2–COAD

Open the COAD breakdown →