RRM1

Across TCGA pan-cancer cohorts, RRM1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RRM1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RRM1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RRM1 is over-expressed in tumor.

CCRCC, COAD, and LSCC are the cancer types where RRM1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRM1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.579	<.001	12	view →
COAD	Female	III,IV	+0.594	<.001	10	view →
LSCC	Male	II,III,IV	+0.974	<.001	9	view →
LUAD	Male	III,IV	+0.666	<.001	9	view →
PDAC	All	All	+0.232	.001	4	view →
OV	All	All	+0.663	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RRM1–CCRCC

Open the CCRCC breakdown →