RRBP1

Across TCGA patient cohorts, RRBP1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRBP1-associated genes across cancer lineages are Annexin-1, eIF4E, and Caspase-7-cleavedD198. Each is linked with RRBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RRBP1-to-partner and partner-to-RRBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RRBP1-low versus RRBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRBP1→partner) and Y-score (partner→RRBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.702	+2.736	<.001	<.001	3	3
UCEC	eIF4E →	+0.240	+3.000	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.575	+2.824	<.001	.034	3	3
UCEC	Chk2_pT68 →	-0.153	-1.990	.005	.002	3	3
UCEC	4E-BP1 →	+0.240	+2.222	.002	.009	3	3
UCEC	ERK2 →	+0.132	+1.440	.021	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Annexin-1 by RRBP1 expression — UCEC

Explore this box plot interactively →