RRBP1

Across TCGA cell cohorts, RRBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,050 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RRBP1-associated genes across cancer lineages are OR1M1, KAT2A, and ASCL3. Each is linked with RRBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRBP1-to-partner and partner-to-RRBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by RRBP1-low versus RRBP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRBP1→partner) and Y-score (partner→RRBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1M1 →	+0.010	+4.058	<.001	.007	3	2
LARGE_INTESTINE	KAT2A →	+0.474	+3.321	<.001	.002	3	2
LARGE_INTESTINE	ASCL3 →	+0.085	+1.491	.009	.009	3	2
LUNG_NSCLC_LUSC	OBP2A →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MROH5 →	+0.070	+4.643	.001	.008	3	1
SOFT_TISSUE	GPR42 →	+0.019	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,050 associations by consensus.

OR1M1 by RRBP1 expression — LUNG_SCLC

Explore this box plot interactively →