RRAGD

Across TCGA patient cohorts, RRAGD mutation is significantly associated with the RNA expression of many other genes, with 1,785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRAGD-associated genes across cancer lineages are MIR6816, MRPS15P1, and ATF4P2. Each is linked with RRAGD in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAGD-to-partner and partner-to-RRAGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6816 grouped by RRAGD-low versus RRAGD-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAGD→partner) and Y-score (partner→RRAGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR6816 →	+0.562	+5.681	<.001	.001	3	2
READ	MRPS15P1 →	+0.107	+4.827	<.001	.002	3	2
READ	ATF4P2 →	+0.064	+5.179	.001	.001	3	2
READ	MIR6870 →	+0.737	+4.280	.001	.007	3	2
LUAD	OR1E3 →	+0.055	+5.554	<.001	.004	3	2
BRCA	H3P34 →	+0.076	+4.841	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,785 associations by consensus.

MIR6816 by RRAGD expression — READ

Explore this box plot interactively →