RRAGC

Across TCGA pan-cancer cohorts, RRAGC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RRAGC data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RRAGC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RRAGC expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where RRAGC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.752	0.541	.009	21	view →
CCRCC	DFS	Median	III,IV	0.123	0.782	.028	6	view →
GBM	DFS	Tertile	All	0.613	0.829	.037	2	view →
PDAC	OS	Quartile	III,IV	1.000	0.864	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RRAGC–HNSC (DFS)

Open the HNSC breakdown →