RRAGB

Across TCGA pan-cancer cohorts, RRAGB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RRAGB data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RRAGB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RRAGB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where RRAGB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.550	0.885	.001	20	view →
CCRCC	DFS	Median	II,III,IV	0.166	0.844	.011	6	view →
PDAC	DFS	Tertile	II,III,IV	0.837	0.316	.016	3	view →
UCEC	OS	Median	All	0.837	1.000	.044	2	view →
GBM	DFS	Quartile	All	0.517	0.759	.046	1	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RRAGB–HNSC (DFS)

Open the HNSC breakdown →