RRAGB

Across TCGA patient cohorts, RRAGB mutation is significantly associated with the RNA expression of many other genes, with 2,541 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRAGB-associated genes across cancer lineages are HMGB1P13, FBLIM1P1, and KIR3DL2. Each is linked with RRAGB in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAGB-to-partner and partner-to-RRAGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P13 grouped by RRAGB-low versus RRAGB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAGB→partner) and Y-score (partner→RRAGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGB1P13 →	+0.100	+3.913	<.001	.006	3	2
LUAD	FBLIM1P1 →	+0.045	+4.629	<.001	.001	3	2
UCEC	KIR3DL2 →	+0.125	+1.423	<.001	.007	3	2
UCEC	RNA5SP413 →	+0.828	+1.518	<.001	.003	3	2
UCEC	RNA5SP417 →	+0.407	+2.029	<.001	<.001	3	2
UCEC	RNU6-1069P →	+0.767	+1.733	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,541 associations by consensus.

HMGB1P13 by RRAGB expression — SKCM

Explore this box plot interactively →