RRAD

Across TCGA patient cohorts, RRAD mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RRAD-associated genes across cancer lineages are LDHAL6DP, CSGALNACT2P2, and LINC02563. Each is linked with RRAD in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAD-to-partner and partner-to-RRAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHAL6DP grouped by RRAD-low versus RRAD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAD→partner) and Y-score (partner→RRAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LDHAL6DP →	+0.045	+4.212	<.001	.007	3	2
UCEC	CSGALNACT2P2 →	+0.171	+4.069	<.001	.002	3	2
SKCM	LINC02563 →	+0.082	+4.130	<.001	.001	3	2
HNSC	RNA5SP234 →	+0.353	+7.954	<.001	.008	3	1
HNSC	RNU6-217P →	+0.392	+7.954	<.001	.008	3	1
SKCM	MIR6499 →	+0.260	+4.039	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

LDHAL6DP by RRAD expression — SKCM

Explore this box plot interactively →