RPUSD3

Across TCGA pan-cancer cohorts, RPUSD3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RPUSD3 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPUSD3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RPUSD3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where RPUSD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.697	.005	18	view →
PDAC	OS	Median	IV	0.962	0.472	.024	3	view →
CCRCC	OS	Quartile	All	0.915	0.686	.032	3	view →
HNSC	DFS	Tertile	III,IV	0.838	1.000	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RPUSD3–LSCC (OS)

Open the LSCC breakdown →