RPUSD2

Across TCGA patient cohorts, RPUSD2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPUSD2-associated genes across cancer lineages are MSH2, MSH6, and PCNA. Each is linked with RPUSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPUSD2-to-partner and partner-to-RPUSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RPUSD2-low versus RPUSD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPUSD2→partner) and Y-score (partner→RPUSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.413	-2.973	<.001	.035	3	1
UCEC	MSH6 →	-0.539	-3.169	<.001	.018	3	1
UCEC	PCNA →	+0.231	+2.459	.026	.020	3	1
UCEC	PDCD4 →	-0.565	-2.999	.012	.035	3	1
UCEC	PR →	-0.242	-2.999	.046	.035	3	1
UCEC	Annexin-1 →	+0.636	+3.019	.012	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSH2 by RPUSD2 expression — UCEC

Explore this box plot interactively →