RPUSD1

Across TCGA cell cohorts, RPUSD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,346 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RPUSD1-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Enzyme-directed rRNA pseudouridine synthesis, and Mitochondrial potassium ion transmembrane transport. Each is linked with RPUSD1 in more than 17 cancer types. Because this analysis shows association rather than direction, both RPUSD1-to-partner and partner-to-RPUSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by RPUSD1-low versus RPUSD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPUSD1→partner) and Y-score (partner→RPUSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA pseudouridine synthesis →	+0.139	+1.100	<.001	<.001	3	18
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	+0.140	+0.751	<.001	<.001	3	17
LUNG_SCLC	Mitochondrial potassium ion transmembrane transport →	+0.137	+0.952	<.001	<.001	3	14
URINARY_TRACT	Peptidyl-methionine modification →	+0.224	+1.177	<.001	.002	3	14
BLOOD_Lymphoma	Ribosome assembly →	+0.084	+1.189	<.001	<.001	3	14
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.142	+0.919	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,346 associations by consensus.

rRNA pseudouridine synthesis by RPUSD1 expression — BONE

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