RPTOR

Across TCGA patient cohorts, RPTOR mutation is significantly associated with the RNA expression of many other genes, with 3,516 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPTOR-associated genes across cancer lineages are CLSPN, MTHFD1, and DCLRE1B. Each is linked with RPTOR in more than 4 cancer types. Because this analysis shows association rather than direction, both RPTOR-to-partner and partner-to-RPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLSPN grouped by RPTOR-low versus RPTOR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTOR→partner) and Y-score (partner→RPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLSPN →	+0.498	+1.668	.002	.003	3	5
SKCM	MTHFD1 →	+0.397	+2.604	<.001	<.001	3	4
COAD	DCLRE1B →	+0.416	+3.321	.001	.009	3	4
COAD	DTL →	+0.512	+2.235	.003	.006	3	4
UCEC	NOM1 →	+0.292	+1.653	.002	<.001	3	4
UCEC	BRI3BP →	+0.530	+2.555	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,516 associations by consensus.

CLSPN by RPTOR expression — UCEC

Explore this box plot interactively →