RPTOR

Across TCGA patient cohorts, RPTOR mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPTOR-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and Akt_pT308. Each is linked with RPTOR in more than 3 cancer types. Because this analysis shows association rather than direction, both RPTOR-to-partner and partner-to-RPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RPTOR-low versus RPTOR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTOR→partner) and Y-score (partner→RPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.946	+2.708	.003	.003	3	4
UCEC	INPP4B →	-0.208	-1.514	.033	.014	3	3
UCEC	Akt_pT308 →	+0.489	+1.415	.010	.040	3	3
UCEC	Cyclin-B1 →	+0.622	+3.906	<.001	<.001	3	3
CESC	IRS1 →	+0.205	+3.000	.001	.033	3	2
UCEC	MSH6 →	-0.353	-1.584	<.001	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by RPTOR expression — COAD

Explore this box plot interactively →