RPTOR

Across TCGA cell cohorts, RPTOR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,258 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPTOR-associated GO terms across cancer lineages are Endosomal transport, Positive regulation of T-helper 17 cell lineage commitment, and TORC1 signaling. Each is linked with RPTOR in more than 15 cancer types. Because this analysis shows association rather than direction, both RPTOR-to-partner and partner-to-RPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by RPTOR-low versus RPTOR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTOR→partner) and Y-score (partner→RPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.062	+1.167	<.001	<.001	3	16
OVARY	Positive regulation of T-helper 17 cell lineage commitment →	+0.230	+0.760	<.001	<.001	3	16
LUNG_NSCLC_LUAD	TORC1 signaling →	+0.135	+0.638	<.001	<.001	3	15
STOMACH	Regulation of pentose-phosphate shunt →	+0.190	+1.282	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.087	+1.307	<.001	<.001	3	14
URINARY_TRACT	Regulation of autophagosome maturation →	+0.087	+0.924	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,258 associations by consensus.

Endosomal transport by RPTOR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →