RPTOR

Across TCGA cell cohorts, RPTOR mutation is significantly associated with the RNA expression of many other genes, with 1,605 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPTOR-associated genes across cancer lineages are RNF145, SLC16A14, and REEP4. Each is linked with RPTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both RPTOR-to-partner and partner-to-RPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF145 grouped by RPTOR-low versus RPTOR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTOR→partner) and Y-score (partner→RPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF145 →	+0.644	+3.459	<.001	.001	3	2
LARGE_INTESTINE	SLC16A14 →	+1.030	+3.541	<.001	<.001	3	2
LARGE_INTESTINE	REEP4 →	+0.631	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	CMTM4 →	+0.634	+2.459	.006	.006	3	2
LARGE_INTESTINE	KCNJ11 →	+0.608	+3.321	.004	.002	3	2
LARGE_INTESTINE	ANKRD39 →	+0.461	+1.936	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,605 associations by consensus.

RNF145 by RPTOR expression — LARGE_INTESTINE

Explore this box plot interactively →