Across TCGA patient cohorts, RPTN mutation is significantly associated with the RNA expression of many other genes, with 819 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RPTN-associated genes across cancer lineages are GPX6, RNU6-1256P, and YBX1P2. Each is linked with RPTN in more than 2 cancer types. Because this analysis shows association rather than direction, both RPTN-to-partner and partner-to-RPTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTN→partner) and Y-score (partner→RPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	GPX6 →	+0.044	+5.653	<.001	.003	3	3
READ	RNU6-1256P →	+0.603	+6.681	<.001	<.001	3	3
SKCM	YBX1P2 →	+0.240	+1.391	<.001	.003	3	3
KIRC	MRPS18BP1 →	+0.213	+4.988	<.001	.009	3	3
SKCM	BCAR1P2 →	+0.015	+1.208	.001	.005	3	3
READ	RN7SL198P →	+0.167	+5.039	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

Exploration

RPTN survival (RNA) · tumor vs normal (RNA) · all RPTN data types