Across TCGA patient cohorts, RPTN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPTN-associated genes across cancer lineages are PR, Annexin_VII, and VHL. Each is linked with RPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both RPTN-to-partner and partner-to-RPTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTN→partner) and Y-score (partner→RPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PR →	-0.120	-3.000	.024	.033	3	1
LUAD	Annexin_VII →	-0.122	-3.153	.045	.019	3	1
UCEC	VHL →	-0.748	-3.321	.035	.010	3	1
UCEC	CD20 →	+0.196	+3.321	.004	.010	3	1
SKCM	AMPK_alpha →	+0.085	+1.280	.034	.045	3	1
SKCM	Rab25 →	-0.143	-1.176	.047	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

RPTN survival (RNA) · tumor vs normal (RNA) · all RPTN data types