Across TCGA cell cohorts, RPTN mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RPTN-associated genes across cancer lineages are CRYGD, TEX26, and PRR20B. Each is linked with RPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both RPTN-to-partner and partner-to-RPTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTN→partner) and Y-score (partner→RPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CRYGD →	+0.037	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.025	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20E →	+0.036	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

RPTN survival (RNA) · tumor vs normal (RNA) · all RPTN data types