Across TCGA pan-cancer cohorts, RPSAP66 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPSAP66’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPSAP66 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPSAP66 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
KIRC, STAD, and THCA are the cancer types where RPSAP66 tumor–normal differential expression is most reproducible.