Across TCGA pan-cancer cohorts, RPSAP53 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RPSAP53’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RPSAP53 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPSAP53 is over-expressed in tumor.
LIHC are the cancer types where RPSAP53 tumor–normal differential expression is most reproducible.