RPS8

Across TCGA patient cohorts, RPS8 mutation is significantly associated with the RNA expression of many other genes, with 1,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS8-associated genes across cancer lineages are VN1R13P, RN7SL104P, and RNU6-74P. Each is linked with RPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS8-to-partner and partner-to-RPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R13P grouped by RPS8-low versus RPS8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS8→partner) and Y-score (partner→RPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	VN1R13P →	+0.479	+3.884	<.001	.008	3	2
LUSC	RN7SL104P →	+0.124	+4.724	<.001	.005	3	2
UCEC	RNU6-74P →	+0.170	+2.899	.003	.003	3	2
UCEC	RN7SL354P →	+0.332	+2.011	<.001	.007	3	2
BRCA	RN7SL673P →	+0.159	+8.055	<.001	.007	3	1
BLCA	HLA-N →	+0.434	+4.533	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,804 associations by consensus.

VN1R13P by RPS8 expression — LUSC

Explore this box plot interactively →