RPS8

Across TCGA patient cohorts, RPS8 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS8-associated genes across cancer lineages are Gab2, p70-S6K_pT389, and PDCD4. Each is linked with RPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS8-to-partner and partner-to-RPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by RPS8-low versus RPS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS8→partner) and Y-score (partner→RPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.344	+2.459	.046	.020	3	1
UCEC	p70-S6K_pT389 →	-0.212	-2.459	.021	.020	3	1
UCEC	PDCD4 →	-0.546	-2.459	.016	.020	3	1
UCEC	STAT3_pY705 →	-0.422	-3.584	<.001	.002	3	1
UCEC	Bak →	+0.265	+3.169	.028	.018	3	1
UCEC	C-Raf →	+0.190	+2.321	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Gab2 by RPS8 expression — UCEC

Explore this box plot interactively →