RPS6P21

Across TCGA pan-cancer cohorts, RPS6P21 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RPS6P21’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RPS6P21 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS6P21 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

UCEC, PRAD, and THCA are the cancer types where RPS6P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	II,III,IV	−0.153	.041	2	view →
PRAD	All	All	+0.039	.046	2	view →
THCA	All	All	−0.033	.015	2	view →
LIHC	All	All	+0.014	.012	2	view →
COAD	All	II,III,IV	+0.103	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RPS6P21–UCEC

Open the UCEC breakdown →