RPS6KL1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RPS6KL1 mutation is significantly associated with the RNA expression of many other genes, with 3,166 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KL1-associated genes across cancer lineages are RNA5SP421, PRSS53, and TRIM36. Each is linked with RPS6KL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KL1-to-partner and partner-to-RPS6KL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KL1→partner) and Y-score (partner→RPS6KL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP421 →+0.720+1.755<.001.00233
UCECPRSS53 →+0.256+3.991<.001<.00132
UCECTRIM36 →+0.942+2.201<.001<.00132
UCECZNF276 →+0.430+3.595<.001.00132
UCECSENP3 →+0.394+2.111.005.00332
UCECTYW3 →+0.392+3.743.002<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,166 associations by consensus.

Exploration