RPS6KL1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RPS6KL1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KL1-associated genes across cancer lineages are p70-S6K_pT389, PCNA, and 53BP1. Each is linked with RPS6KL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KL1-to-partner and partner-to-RPS6KL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KL1→partner) and Y-score (partner→RPS6KL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp70-S6K_pT389 →-0.230-2.000<.001.02932
UCECPCNA →+0.194+2.321.012.03332
UCEC53BP1 →+0.296+2.321.016.03332
UCECDi-Ras3 →-0.189-2.986<.001<.00132
UCEC14-3-3_beta →-0.135-3.780<.001<.00131
UCECEGFR_pY1068 →-0.239-1.906.008.01531
Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

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