RPS6KC1

Across TCGA pan-cancer cohorts, RPS6KC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPS6KC1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPS6KC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RPS6KC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where RPS6KC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.802	0.954	.001	22	view →
HNSC	DFS	Median	All	0.409	0.860	.024	14	view →
CCRCC	DFS	Quartile	All	0.503	1.000	.012	11	view →
GBM	OS	Tertile	All	0.465	0.657	.018	9	view →
PDAC	DFS	Quartile	All	0.894	0.792	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPS6KC1–LSCC (OS)

Open the LSCC breakdown →