RPS6KC1

Across TCGA patient cohorts, RPS6KC1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KC1-associated genes across cancer lineages are GAPDH, MEK1, and Notch1. Each is linked with RPS6KC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KC1-to-partner and partner-to-RPS6KC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RPS6KC1-low versus RPS6KC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KC1→partner) and Y-score (partner→RPS6KC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GAPDH →	+0.678	+3.169	.003	.019	3	2
UCEC	MEK1 →	+0.361	+2.736	.001	<.001	3	2
UCEC	Notch1 →	+0.148	+3.100	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.397	+3.999	<.001	<.001	3	2
UCEC	PDCD4 →	-0.515	-1.643	<.001	.003	3	2
UCEC	S6_pS240_S244 →	+0.371	+1.502	.003	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GAPDH by RPS6KC1 expression — BLCA

Explore this box plot interactively →