RPS6KC1

Across TCGA cell cohorts, RPS6KC1 mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPS6KC1-associated genes across cancer lineages are GKN1, H1-8, and PSMA6. Each is linked with RPS6KC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KC1-to-partner and partner-to-RPS6KC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GKN1 grouped by RPS6KC1-low versus RPS6KC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KC1→partner) and Y-score (partner→RPS6KC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GKN1 →	+0.078	+5.201	<.001	.006	3	1
BLOOD_Leukemia	H1-8 →	+0.022	+4.922	<.001	.009	3	1
LARGE_INTESTINE	PSMA6 →	+0.405	+3.502	.003	.001	3	1
LARGE_INTESTINE	BMF →	-1.040	-3.416	.002	.002	3	1
LARGE_INTESTINE	ASPN →	+0.050	+3.163	<.001	<.001	3	1
LARGE_INTESTINE	TTK →	+0.638	+3.502	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

GKN1 by RPS6KC1 expression — BLOOD_Leukemia

Explore this box plot interactively →