RPS6KB2

Across TCGA patient cohorts, RPS6KB2 mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KB2-associated genes across cancer lineages are RNU6-820P, MIR615, and TRAJ26. Each is linked with RPS6KB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KB2-to-partner and partner-to-RPS6KB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-820P grouped by RPS6KB2-low versus RPS6KB2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB2→partner) and Y-score (partner→RPS6KB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-820P →	+0.241	+4.259	.005	.002	3	2
LUSC	MIR615 →	+0.233	+3.279	.003	.009	3	2
LUSC	TRAJ26 →	+0.588	+3.041	<.001	.008	3	2
LUSC	RNA5SP53 →	+0.296	+3.645	<.001	.002	3	2
LUSC	RNU2-64P →	+0.172	+5.318	<.001	<.001	3	2
LUSC	KRTAP19-9P →	+0.169	+6.014	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

RNU6-820P by RPS6KB2 expression — BRCA

Explore this box plot interactively →