RPS6KB2

Across TCGA patient cohorts, RPS6KB2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KB2-associated genes across cancer lineages are Heregulin, Myosin-IIa, and PCNA. Each is linked with RPS6KB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KB2-to-partner and partner-to-RPS6KB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by RPS6KB2-low versus RPS6KB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB2→partner) and Y-score (partner→RPS6KB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.140	-3.000	.031	.036	3	1
UCEC	Myosin-IIa →	+0.254	+2.177	.008	.035	3	1
UCEC	PCNA →	+0.300	+3.321	.008	.010	2	2
UCEC	Di-Ras3 →	-0.219	-3.321	.004	.010	3	1
UCEC	4E-BP1 →	+0.333	+2.837	.019	.035	2	1
UCEC	MEK1 →	+0.600	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Heregulin by RPS6KB2 expression — UCEC

Explore this box plot interactively →