RPS6KB2

Across TCGA cell cohorts, RPS6KB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,805 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RPS6KB2-associated GO terms across cancer lineages are CAAX-box protein processing, Regulation of attachment of mitotic spindle microtubules to kinetochore, and Positive regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with RPS6KB2 in more than 15 cancer types. Because this analysis shows association rather than direction, both RPS6KB2-to-partner and partner-to-RPS6KB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAX-box protein processing grouped by RPS6KB2-low versus RPS6KB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB2→partner) and Y-score (partner→RPS6KB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAAX-box protein processing →	+0.248	+1.064	<.001	<.001	3	16
LUNG_SCLC	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.134	+0.493	<.001	.009	3	10
LUNG_SCLC	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.150	+0.600	<.001	.004	3	10
BONE	mRNA alternative polyadenylation →	+0.103	+0.859	.001	<.001	3	10
SOFT_TISSUE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.144	+0.838	.001	<.001	3	10
PANCREAS	Cell cycle phase transition →	+0.042	+0.488	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,805 associations by consensus.

CAAX-box protein processing by RPS6KB2 expression — BONE

Explore this box plot interactively →