RPS6KB2

Across TCGA cell cohorts, RPS6KB2 mutation is significantly associated with the protein abundance of many other proteins, with 62 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RPS6KB2-associated proteins across cancer lineages are DCTN2, C19orf54, and ADA. Each is linked with RPS6KB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KB2-to-partner and partner-to-RPS6KB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCTN2 grouped by RPS6KB2-low versus RPS6KB2-high in BLOOD_Leukemia.

mutation associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB2→partner) and Y-score (partner→RPS6KB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCTN2 →	+0.531	+3.395	<.001	.001	3	1
BLOOD_Leukemia	C19orf54 →	-0.997	-3.105	<.001	.009	3	1
BLOOD_Leukemia	ADA →	+2.266	+3.321	<.001	.006	3	1
BLOOD_Leukemia	DCTN1 →	+0.437	+3.504	<.001	.002	3	1
BLOOD_Leukemia	DDX52 →	-0.644	-3.321	<.001	.006	3	1
BLOOD_Leukemia	TFB1M →	-0.707	-3.243	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

DCTN2 by RPS6KB2 expression — BLOOD_Leukemia

Explore this box plot interactively →