RPS6KB1

Across TCGA pan-cancer cohorts, RPS6KB1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RPS6KB1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RPS6KB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RPS6KB1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where RPS6KB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6KB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.451	<.001	12	view →
HNSC	All	All	+0.074	.015	8	view →
LUAD	Female	All	+0.153	<.001	6	view →
COAD	All	All	−0.312	<.001	5	view →
LSCC	All	All	+0.098	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RPS6KB1–CCRCC

Open the CCRCC breakdown →