RPS6KA5

Across TCGA patient cohorts, RPS6KA5 mutation is significantly associated with the RNA expression of many other genes, with 2,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA5-associated genes across cancer lineages are ENO2, RNA5SP67, and RNA5SP412. Each is linked with RPS6KA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KA5-to-partner and partner-to-RPS6KA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENO2 grouped by RPS6KA5-low versus RPS6KA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA5→partner) and Y-score (partner→RPS6KA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENO2 →	+0.664	+1.917	.001	.009	3	3
LUSC	RNA5SP67 →	+0.321	+3.091	<.001	.007	3	3
UCEC	RNA5SP412 →	+0.340	+1.552	.004	.007	3	3
UCEC	TRMU →	+0.500	+3.279	<.001	<.001	3	2
UCEC	DHRS2 →	+1.079	+2.747	<.001	<.001	3	2
UCEC	UQCRC1 →	+0.333	+1.957	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,735 associations by consensus.

ENO2 by RPS6KA5 expression — UCEC

Explore this box plot interactively →