RPS6KA5

Across TCGA patient cohorts, RPS6KA5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA5-associated genes across cancer lineages are FASN, ACC1, and Rad50. Each is linked with RPS6KA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KA5-to-partner and partner-to-RPS6KA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RPS6KA5-low versus RPS6KA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA5→partner) and Y-score (partner→RPS6KA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.338	+2.137	.011	.001	3	2
UCEC	ACC1 →	+0.280	+2.598	.023	.005	3	2
UCEC	Rad50 →	-0.173	-1.687	.036	.040	3	2
UCEC	Annexin-1 →	+0.562	+2.242	.001	.005	3	2
UCEC	STAT3_pY705 →	-0.302	-1.502	<.001	.025	3	2
UCEC	4E-BP1 →	+0.338	+3.837	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

FASN by RPS6KA5 expression — UCEC

Explore this box plot interactively →