RPS6KA5

Across TCGA cell cohorts, RPS6KA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,061 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RPS6KA5-associated GO terms across cancer lineages are Regulation of mitotic cytokinesis, Mitotic DNA damage checkpoint signaling, and Negative regulation of cell cycle process. Each is linked with RPS6KA5 in more than 11 cancer types. Because this analysis shows association rather than direction, both RPS6KA5-to-partner and partner-to-RPS6KA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic cytokinesis grouped by RPS6KA5-low versus RPS6KA5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA5→partner) and Y-score (partner→RPS6KA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of mitotic cytokinesis →	+0.127	+1.060	.001	.001	3	12
LARGE_INTESTINE	Mitotic DNA damage checkpoint signaling →	+0.069	+0.981	<.001	<.001	3	11
BLOOD_Leukemia	Negative regulation of cell cycle process →	+0.045	+0.690	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.042	+0.834	.003	.003	3	10
LUNG_NSCLC_LUSC	Mitotic DNA integrity checkpoint signaling →	+0.068	+0.951	.001	.005	3	10
LUNG_SCLC	Centrosome cycle →	+0.079	+1.253	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,061 associations by consensus.

Regulation of mitotic cytokinesis by RPS6KA5 expression — OESOPHAGUS

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