RPS6KA5

Across TCGA cell cohorts, RPS6KA5 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RPS6KA5-associated genes across cancer lineages are TEX55, HES3, and OR1L1. Each is linked with RPS6KA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA5-to-partner and partner-to-RPS6KA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX55 grouped by RPS6KA5-low versus RPS6KA5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA5→partner) and Y-score (partner→RPS6KA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TEX55 →	+0.056	+5.321	<.001	.005	3	1
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
CNS	OR1L1 →	+0.049	+5.754	<.001	.002	3	1
CNS	PRM3 →	+0.175	+5.754	<.001	.002	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TEX55 by RPS6KA5 expression — CNS

Explore this box plot interactively →