RPS6KA4

Across TCGA patient cohorts, RPS6KA4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,998 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RPS6KA4-associated genes across cancer lineages are PRAME, EHD1, and BTN3A3. Each is linked with RPS6KA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both RPS6KA4-to-partner and partner-to-RPS6KA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RPS6KA4 versus PRAME in LSCC, with a Pearson correlation of -0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA4→partner) and Y-score (partner→RPS6KA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRAME →	-2.276	-0.417	<.001	<.001	3	6
BRCA	EHD1 →	+0.525	+0.269	<.001	<.001	3	5
CCRCC	BTN3A3 →	+0.650	+0.160	<.001	.002	3	5
UCEC	PYHIN1 →	+0.785	+0.252	.007	.008	3	5
GBM	CCDC88B →	+0.649	+0.327	<.001	<.001	3	5
HNSC	EHBP1L1 →	+0.679	+0.405	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,998 associations by consensus.

RPS6KA4 vs PRAME — LSCC

Explore this scatter interactively →