RPS6KA4

Across TCGA cell cohorts, RPS6KA4 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPS6KA4-associated genes across cancer lineages are C1orf52, GTSF1L, and GPR171. Each is linked with RPS6KA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA4-to-partner and partner-to-RPS6KA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf52 grouped by RPS6KA4-low versus RPS6KA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA4→partner) and Y-score (partner→RPS6KA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf52 →	+0.663	+3.502	<.001	.001	3	2
LUNG_NSCLC_LUAD	GTSF1L →	+0.045	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPR171 →	+0.031	+4.093	<.001	.004	3	1
BLOOD_Leukemia	ASZ1 →	+0.260	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CCKAR →	+0.038	+4.409	<.001	.005	3	1
BLOOD_Leukemia	GPR101 →	+0.133	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

C1orf52 by RPS6KA4 expression — LARGE_INTESTINE

Explore this box plot interactively →