RPS6KA3

Across TCGA patient cohorts, RPS6KA3 mutation is significantly associated with the RNA expression of many other genes, with 5,696 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA3-associated genes across cancer lineages are OR9G4, DPH6, and MZT1P1. Each is linked with RPS6KA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KA3-to-partner and partner-to-RPS6KA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G4 grouped by RPS6KA3-low versus RPS6KA3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA3→partner) and Y-score (partner→RPS6KA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR9G4 →	+0.032	+5.040	.003	.002	3	3
UCEC	DPH6 →	+0.341	+2.343	<.001	<.001	3	3
SKCM	MZT1P1 →	+0.134	+3.449	<.001	.002	3	2
UCEC	TAF9 →	+0.695	+3.000	<.001	<.001	3	2
BRCA	CCDC121P1 →	+0.261	+4.539	<.001	.005	3	2
UCEC	GAS6-DT →	-0.360	-1.267	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,696 associations by consensus.

OR9G4 by RPS6KA3 expression — BLCA

Explore this box plot interactively →