RPS6KA3

Across TCGA patient cohorts, RPS6KA3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA3-associated genes across cancer lineages are C-Raf, p62 Lck ligand, and p70-S6K. Each is linked with RPS6KA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KA3-to-partner and partner-to-RPS6KA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by RPS6KA3-low versus RPS6KA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA3→partner) and Y-score (partner→RPS6KA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.165	+2.058	<.001	<.001	3	3
UCEC	p62 Lck ligand →	+0.340	+3.169	<.001	<.001	3	2
UCEC	p70-S6K →	+0.109	+1.196	.049	.011	3	2
UCEC	S6_pS240_S244 →	+0.234	+1.415	.045	.043	3	2
UCEC	Annexin_VII →	-0.089	-0.999	.025	.042	3	2
UCEC	BRD4 →	+0.200	+2.321	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

C-Raf by RPS6KA3 expression — UCEC

Explore this box plot interactively →