RPS6KA3

Across TCGA cell cohorts, RPS6KA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,683 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RPS6KA3-associated GO terms across cancer lineages are TORC1 signaling, Golgi vesicle transport, and Endosomal transport. Each is linked with RPS6KA3 in more than 14 cancer types. Because this analysis shows association rather than direction, both RPS6KA3-to-partner and partner-to-RPS6KA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TORC1 signaling grouped by RPS6KA3-low versus RPS6KA3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA3→partner) and Y-score (partner→RPS6KA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TORC1 signaling →	+0.138	+1.324	<.001	<.001	3	15
BONE	Golgi vesicle transport →	+0.076	+1.020	<.001	<.001	3	12
SKIN	Endosomal transport →	+0.054	+1.157	<.001	<.001	3	11
BONE	Viral gene expression →	+0.092	+0.736	<.001	.001	3	11
BONE	Post-Golgi vesicle-mediated transport →	+0.076	+1.040	.003	<.001	3	11
KIDNEY	TOR signaling →	+0.086	+1.003	.007	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,683 associations by consensus.

TORC1 signaling by RPS6KA3 expression — LUNG_SCLC

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