RPS6KA1

Across TCGA pan-cancer cohorts, RPS6KA1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RPS6KA1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RPS6KA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPS6KA1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where RPS6KA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	1.000	0.841	.041	12	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
UCEC	OS	Tertile	All	1.000	0.883	.018	10	view →
LUAD	DFS	Median	II,III,IV	0.673	0.982	.003	9	view →
CCRCC	DFS	Tertile	All	0.839	0.618	.020	7	view →
GBM	DFS	Quartile	All	0.321	0.624	.008	5	view →
LSCC	DFS	Median	II,III,IV	0.988	0.848	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RPS6KA1–COAD (DFS)

Open the COAD breakdown →