RPS6KA1

Across TCGA cell cohorts, RPS6KA1 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RPS6KA1-associated genes across cancer lineages are PRRG3, GKN1, and C9orf92. Each is linked with RPS6KA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA1-to-partner and partner-to-RPS6KA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRRG3 grouped by RPS6KA1-low versus RPS6KA1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA1→partner) and Y-score (partner→RPS6KA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRRG3 →	+0.713	+4.927	<.001	.001	3	2
BLOOD_Lymphoma	GKN1 →	+0.750	+4.350	<.001	.005	3	2
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	1
BLOOD_Lymphoma	MYH1 →	+0.045	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	H2BW1 →	+0.296	+4.927	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

PRRG3 by RPS6KA1 expression — BLOOD_Lymphoma

Explore this box plot interactively →