RPS6KA1

Across TCGA cell cohorts, RPS6KA1 mutation is significantly associated with the mutation status of many other genes, with 4,301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPS6KA1-associated genes across cancer lineages are SPTBN4, PRRC2B, and ITGB4. Each is linked with RPS6KA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RPS6KA1-to-partner and partner-to-RPS6KA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTBN4 grouped by RPS6KA1-low versus RPS6KA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA1→partner) and Y-score (partner→RPS6KA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPTBN4 →	+1.781	+3.602	.006	.006	1	5
BLOOD_Leukemia	PRRC2B →	+2.560	+4.364	.002	.002	1	4
LARGE_INTESTINE	ITGB4 →	+1.693	+3.506	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	MBTPS1 →	+4.539	+5.193	<.001	<.001	1	4
BLOOD_Leukemia	SPTBN2 →	+2.753	+4.544	.001	.001	1	4
UPPER_AERODIGESTIVE_TRACT	DNHD1 →	+2.731	+4.070	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,301 associations by consensus.

SPTBN4 by RPS6KA1 expression — LARGE_INTESTINE

Explore this box plot interactively →